Chronic Lymphocytic Leukemia: New Research
This book presents recent and important research on Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, which is a type of leukemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age; over 75% of new cases are diagnosed in patients over age 50.
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abnormalities activation AIHA alemtuzumab antibodies antigen apoptosis apoptotic associated autocrine autoimmune B-cell chronic lymphocytic B-CLL B-CLL cells BAFF and APRIL Bcl-2 family Bcl-x Bcl-x protein Blood C/EBPp Cancer caspase CD38 expression CD40-activated CD5+ cell death cell line chemotherapy chlorambucil chromosomal chronic lymphocytic leukemia clinical CLL B cells CLL cells CLL patients CLL samples CLL-B clone correlation cyclophosphamide cytokines cytotoxic deletion detected differentiation fludarabine function genetic genomic Haematol Haematology identified IgVH mutation immune immunoglobulin Immunol increased inhibitor inhibits interaction Interleukin kinase leukemic cells levels ligand lymphocytic leukemia cells lymphoid lymphoma malignant mediated microarray molecules monoclonal monoclonal antibody monocytes mRNA mutation mutation status myeloid NF-kB overexpression pathway phenotype phosphorylation prognostic factors prognostic markers proliferation receptor regulation response Rituximab role signaling soluble splenectomy splenic stimulation studies survival therapeutic therapy Tisl TNF-a transcription factors treatment tumor necrosis unmutated CLL upregulated VH mutation vitro vivo