Tetracyclines in Biology, Chemistry and Medicine

封面
M. Nelson, W. Hillen, R.A. Greenwald
Springer Science & Business Media, 2001年10月1日 - 336 頁
2 書評
The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).
 

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內容

The chemistry and cellular biology of the tetracyclines
3
Proton and metal ion binding of tetracyclines
65
Tetracyclinedependent gene regulation A versatile tool for all organisms
105
Gene regulation by the tetracyclineinducible Tet represseroperator system molecular mechanisms at atomic resolution
107
Regulation of gene expression in yeast and plants by tetracyclinedependent regulatory systems
125
Tetracyclines in the control of gene expression in eukaryotes
139
Tetracyclineregulated gene expression to study oncogenes in vivo
159
Interactions of tetracyclines with RNA
175
Tetracycline consumption in prehistory
217
antimicrobial and nonantimicrobial mechanisms
235
Inhibition of matrix metalloproteinases MMPs by tetracyclines
265
Structurefunction studies of doxycycline effects on matrix metalloproteinase activity and cartilage degeneration
281
Regulation of inflammatory mediators by tetracyclines
293
Tetracydines and autoimmunity
309
Tetracycline photodynamics
323
Subject index
331

Use of tetracyclines as non antimicrobial medicinal agents
195
Biological nonantibiotic properties of semi synthetic and chemically modified tetracyclines a structured annotated bibliography
197

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