Science of Synthesis: Houben-Weyl Methods of Molecular Transformations
Thieme, 2000 - 850 頁
New edition of the acclaimed reference series, Houben-Weyl. This new ed. is published in English and is available in both print and electronic formats. Clear and systematic, Science of Synthesis provides practical solutions and offers a route through the mass of information available in the primary literature. This one-stop reference tool is: Comprehensive: contains synthetic models selected by world-renowned experts, with full experimental procedures and background information. Reliable: the international editorial board is made up of distinguished chemists with unparalleled experience and competence. Logical and easy-to-navigate: information is organized in a hierarchical system based on the compound or functional group to be synthesized. Authoritative: critically evaluates the preparative applicability and significance of the synthetic methods. Wide-ranging: considers methods from journals, books, and patent literature from the early 1800s up to the present day and presents important synthetic methods for all classes of compounds.
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Abstr acetic achieved acid added addition affords alcohols aliphatic alkenes alkyl allylic amounts aqueous atom benzene benzyl bond bromine bromoalkanes carbon carbon tetrachloride catalyst CAUTION CCl4 CH₂Cl₂ Chem chloride chloroalkanes chromatography Cl₂ combined complex compounds concentrated containing conversion cooled corresponding derivatives distilled dried equiv esters Et₂O ether example excess extracted filtrate flask formation formed functional give H H H H₂O heating hydrogen bromide intermediate iodide iodine iodoalkanes leads MeCN metal Method methyl mixture mmol obtained organic layer oxide Ph Ph prepared presence primary procedure proceeds purified radical Ratio react reaction reactivity reagent reduced pressure reflux removed residue resulting ring opening salts Scheme secondary selective silica gel sodium soln solvent stirred substitution substrates Synthesis Table temperature tertiary Tetrahedron Lett tion Torr toxic treatment Typical Variation washed yield